Blood-Brain Barrier Breakdown and Cognitive Impairment in Humans

By imaging the living human brain, Montagne et al. show an age-dependent blood-brain barrier (BBB) breakdown in the hippocampus, a region critical for learning and memory, which worsens with mild cognitive impairment and correlates with injury to BBB-associated cell pericyte. For more information, see Montagne et al. in Neuron 85(2),

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